BMS-986176

BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research[1].

Product Specifications

CAS Number

[1815613-42-3]

Product Name Alternative

LX-9211; AAK1-IN-1

UNSPSC

12352005

Target

AAK1

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bms-986176.html

Purity

98.79

Solubility

DMSO : 220 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@](N)(C)COC1=C(C(F)F)N=C(C2=CC(C(F)F)=NC=C2)C=C1

Molecular Formula

C19H23F4N3O

Molecular Weight

385.40

References & Citations

[1]Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.|[2]Guanglin Luo, et al. Discovery of (S) -1- ((2',6-Bis (difluoromethyl) -[2,4'-bipyridin]-5-yl) oxy) -2,4-dimethylpentan-2-amine (BMS-986176/LX-9211) : A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022 Mar 24;65 (6) :4457-4480.