Rucaparib (phosphate)
Rucaparib (AG014699) phosphate is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib phosphate is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib phosphate has the potential for castration-resistant prostate cancer (CRPC) research[1][2][3][4].
Product Specifications
CAS Number
[459868-92-9]
Product Name Alternative
AG-014699 (phosphate) ; PF-01367338 (phosphate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Rucaparib-phosphate.html
Purity
99.76
Solubility
DMSO : ≥ 33 mg/mL|H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=P(O)(O)O.FC1=CC2=C3C(CCNC2=O)=C(C4=CC=C(CNC)C=C4)NC3=C1
Molecular Formula
C19H21FN3O5P
Molecular Weight
421.36
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PARP1; PARP2; PARP3
Citation 01
Available Sizes
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