pan-KRAS degrader 1
Product Specifications
UNSPSC Description
pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant Ki value of 25 nM for KRASG12V .pan-KRAS degrader 1 has antitumor activity[1].
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-degrader-1.html
Smiles
NC(S1)=C(C#N)C2=C1CCC[C@@]2(C3=NC(C4=NC(N5[C@@H](C)CNCCC5)=NC=C4)=NO3)C
Molecular Weight
450.56
References & Citations
[1]Popow J, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024 Sep 20;385(6715):1338-1347.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162960/pan-KRAS-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162960/
Clinical Information
No Development Reported
CAS Number
2937327-83-6
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