Fluorobexarotene
Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene[1].
Product Specifications
CAS Number
[1190848-23-7]
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fluorobexarotene.html
Purity
99.48
Solubility
DMSO : 36 mg/mL (ultrasonic; warming)
Smiles
O=C(O)C1=CC=C(C(C2=C(C)C=C3C(C)(C)CCC(C)(C)C3=C2)=C)C=C1F
Molecular Formula
C24H27FO2
Molecular Weight
366.47
References & Citations
[1]Wagner CE, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1- (3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl) ethynyl]benzoic acid (bexarotene) . J Med Chem. 2009 Oct 8;52 (19) :5950-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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