Miravirsen

Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection[1][2].

Product Specifications

CAS Number

[1072874-90-8]

Product Name Alternative

SPC-3649

UNSPSC

12352208

Target

HCV; MicroRNA

Type

Oligonucleotides

Related Pathways

Anti-infection; Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/miravirsen.html

Purity

98.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Miravirsen]

Molecular Weight

4967.00

References & Citations

[1]Luca F R Gebert, et al. Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res. 2014 Jan;42 (1) :609-21.|[2]Elmén J, et, al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 2008 Mar;36 (4) :1153-62.