RU-302
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
Product Specifications
CAS Number
[1182129-77-6]
UNSPSC
12352005
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ru-302.html
Purity
98.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1SCC2=C(C)ON=C2C)N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3
Molecular Formula
C24H24F3N3O2S
Molecular Weight
475.53
References & Citations
[1]Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Transcription Elongation Factor B Polypeptide 2 Human Recombinant (TCEB2 Human)
Transcription Elongation Factor B Polypeptide 2 Human Recombinant (TCEB2 Human)
Transcription Elongation Factor B Polypeptide 2 Human Recombinant (TCEB2 Human)
