Gp(2′-5′)Ap (sodium)
Product Specifications
UNSPSC Description
Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.
Target Antigen
Others
Type
Oligonucleotides
Related Pathways
Others
Assay Protocol
https://www.medchemexpress.com/gp-2-5-ap-sodium.html
Smiles
O[C@H]1[C@@H](OP(OC[C@@H]2[C@@H](OP(O[Na])(O[Na])=O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)(O[Na])=O)[C@H](N5C(N=C(N)NC6=O)=C6N=C5)O[C@@H]1CO
Molecular Weight
758.37
References & Citations
[1]Dey RJ, Dey B, Zheng Y, et al. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nat Chem Biol. 2017;13(2):210-217.|[2]Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013;498(7454):380-384.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159857/Gp-2-5-Ap-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159857/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
