Cortodoxone

Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation[1][2].

Product Specifications

CAS Number

[152-58-9]

Product Name Alternative

11-Deoxycortisol; cortexolone; Reichstein's substance S

UNSPSC

12352211

Hazard Statement

H410

Target

Endogenous Metabolite; Glucocorticoid Receptor

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Cortodoxone.html

Purity

98.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

Molecular Formula

C21H30O4

Molecular Weight

346.47

Precautions

H410

References & Citations

[1]Gjerde H, et al. 11-Deoxycortisol induces hepatic tryptophan oxygenase in rats. Acta Pharmacol Toxicol (Copenh) . 1985 Jul;57 (1) :36-9. |[2]Peng C, et al. 11-deoxycortisol positively correlates with T cell immune traits in physiological conditions. EBioMedicine. 2024 Jan;99:104935.