YCH1899
YCH1899 is an orally active PARP inhibitor, with an IC5050 values of 0.89 and 1.13 nM, respectively. YCH1899 has acceptable pharmacokinetic properties in rats[1].
Product Specifications
CAS Number
[3032451-66-1]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ych1899.html
Purity
99.86
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NN=C(C2=CC=CC=C21)CC3=CC=C(C(C(N4CCN5C(C4)=NN=C5C6=CC=C(O6)Br)=O)=C3)F
Molecular Formula
C25H18BrFN6O3
Molecular Weight
549.35
References & Citations
[1]Sun Y, et al. YCH1899, a Highly Effective Phthalazin-1 (2H) -one Derivative That Overcomes Resistance to Prior PARP Inhibitors. J Med Chem. 2023 Aug 21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP10; PARP12; PARP14; PARP15; PARP2; PARP3; PARP4; PARP7; TNKS1/PARP5A; TNKS2/PARP5B
Available Sizes
Curated Selection
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