Artemisitene

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].

Product Specifications

CAS Number

[101020-89-7]

UNSPSC

12352005

Target

Apoptosis; Keap1-Nrf2; Topoisomerase

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/artemisitene.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C=C1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(OO4)[C@@](OC1=O)([H])O[C@@]34C

Molecular Formula

C15H20O5

Molecular Weight

280.32

References & Citations

[1]Weimin Chen, et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30 (7) :2500-10.|[2]Jian Chen, et al. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Oncogene. 2018 Sep;37 (37) :5079-5087.