Nitazoxanide

Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM[1]. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model[2].

Product Specifications

CAS Number

[55981-09-4]

Product Name Alternative

NTZ; NSC 697855

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Influenza Virus; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nitazoxanide.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2OC(C)=O

Molecular Formula

C12H9N3O5S

Molecular Weight

307.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Rossignol JF, et al. Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level. J Biol Chem. 2009 Oct 23;284 (43) :29798-808.|[2]Zixue Shi, et al. Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model. Virol J. 2014 Jan 23;11:10.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP3-06228MFV450 0.1 mL

Rabbit Polyclonal KHDC1 Antibody [mFluor Violet 450 SE]

Ask

View Details

TL301004V 500 µL Each

TMEM146 (CATSPERD) Human shRNA Lentiviral Particle (Locus ID 257062)

Ask

View Details

NBP2-59395G 0.1 mL

Mouse Monoclonal 14-3-3 epsilon Antibody (4F8) [DyLight 488]

Ask

View Details