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Windorphen

Windorphen is a Wnt/β-catenin signal inhibitor that specifically targets the function of the c-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP[1].

Product Specifications

CAS Number

[19881-70-0]

Product Name Alternative

CP 526555 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Acetyltransferase; Wnt; β-catenin

Type

Reference compound

Related Pathways

Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/windorphen.html

Purity

99.75

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C/C(C1=CC=C(OC)C=C1)=C(Cl)/C2=CC=C(OC)C=C2

Molecular Formula

C17H15ClO3

Molecular Weight

302.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Jijun Hao, et al. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep. 2013 Sep 12;4 (5) :898-904.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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