Tafamidis

Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis[1].

Product Specifications

CAS Number

[594839-88-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endoplasmic Reticulum Oxidoreductase 1 (ERO1)

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tafamidis.html

Purity

99.89

Solubility

DMSO : 37.5 mg/mL (ultrasonic) |Ethanol : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O

Molecular Formula

C14H7Cl2NO3

Molecular Weight

308.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109 (24) : p. 9629-34.