SB 202190 (hydrochloride)
Product Specifications
UNSPSC Description
SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3].
Target Antigen
Apoptosis; Autophagy; Organoid; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;MAPK/ERK Pathway;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-202190-hydrochloride.html
Purity
99.84
Solubility
DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
OC1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1.[H]Cl
Molecular Weight
367.80
References & Citations
[1]Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.|[2]Yang S, et al. Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia. Biomed Res Int. 2013;2013:215798.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10295A/SB-202190-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10295A/SB-202190-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
350228-36-3
Available Sizes
Curated Selection
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