MOUSE ANTI HUMAN SIGLEC-10

Store at +4°C or at -20°C if prefered.<br>Storage in forst-free freezers is not recommended.<br>This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

SIGLEC-10<br>Mouse anti Human Siglec-10 antibody, clone 5G6 recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and membrane of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preerentially binds to glycoconjugates containing alpha-2,3- or alpha -2,6- linked sialic acid. Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on edothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Mouse anti Human Siglec-10 antibody, clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9.

[sialic acid-binding Ig-like lectin 10 isoform 2; Sialic acid-binding Ig-like lectin 10; sialic acid-binding Ig-like lectin 10; sialic acid binding Ig-like lectin 10 Ig-like lectin 7; siglec-like gene 2; siglec-like protein 2; sialic acid binding Ig-like lectin 10; Siglec-like protein 2]