R18 (TFA)

R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].

Product Specifications

Product Name Alternative

PHCVPRDLSWLDLEANMCLP (TFA)

UNSPSC

12352209

Target

Raf

Type

Peptides

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r18-tfa.html

Purity

99.91

Solubility

H2O : ≥ 25 mg/mL

Smiles

OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC(C)C)NC([C@H](CS)NC([C@H](CCSC)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CS)NC([C@@H](NC([C@@H]3CCCN3)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O