Astin C

Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers[1][2][3].

Product Specifications

CAS Number

[148057-23-2]

Product Name Alternative

Asterin

UNSPSC

12352209

Target

HSV; STING

Type

Peptides

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/astin-c.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C[C@H](C1=CC=CC=C1)NC([C@H](CO)NC([C@@H](CC)N2)=O)=O)N[C@@H](CC)C(N3[C@]([C@H](Cl)[C@H](Cl)C3)([H])C2=O)=O

Molecular Formula

C25H33Cl2N5O6

Molecular Weight

570.47

References & Citations

[1]Antoine Vassaux, et al. Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions. Biotechnol J. 2019 Aug;14 (8) :e1800624. |[2]Li S, et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018 Dec 18;25 (12) :3405-3421.e7.|[3]Morita H, et al. Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus. Chem Pharm Bull (Tokyo) . 1996 May;44 (5) :1026-32.