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Phosphoramide mustard (cyclohexanamine)

Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage[1][2].

Product Specifications

UNSPSC

12352211

Hazard Statement

H302+H312+H332

Target

DNA Alkylator/Crosslinker; Drug Metabolite

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phosphoramide-mustard-cyclohexanamine.html

Purity

98.0

Solubility

H2O : ≥ 50 mg/mL

Smiles

O=P(N(CCCl)CCCl)(N)O.NC1CCCCC1

Molecular Formula

C10H24Cl2N3O2P

Molecular Weight

320.20

Precautions

H302+H312+H332

References & Citations

[1]Shanthi Ganesan, et al. Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells. Toxicol Appl Pharmacol. 2015 Feb 1; 282 (3) : 252–258.|[2]S Genka, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol. 1990;27 (1) :1-7.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-137316A/Phosphoramide-mustard-cyclohexanamine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-137316A/Phosphoramide-mustard-cyclohexanamine-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Climacteric. 2025 Jan 10:1-12.|Int J Nanomedicine. 2025 Aug 22:20:10195-10212.|J Funct Foods. 2025 Jun.|Sci Rep. 2024 Aug 16;14 (1) :19008.|Tufts University. 2025.|SSRN. 2024 Mar 21.|Stem Cell Res Ther. 2024 Apr 5;15 (1) :97.

CAS Number

[1566-15-0]

Available Sizes

Curated Selection

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