MCAAD-3

MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice[1].

Product Specifications

CAS Number

[1625629-51-7]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mcaad-3.html

Purity

96.12

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(C1=CC=C(C=C1)/C=C/C=C/C=C(C#N)/C(OC)=O)C

Molecular Formula

C17H18N2O2

Molecular Weight

282.34

References & Citations

[1]Fu H, et al. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes. Chem Commun (Camb) . 2014 Oct 14;50 (80) :11875-8.