Dorzagliatin (Standard)
Product Specifications
UNSPSC Description
Dorzagliatin (Standard) is the analytical standard of Dorzagliatin. This product is intended for research and analytical applications. Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1].
Target Antigen
Glucokinase
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dorzagliatin-standard.html
Smiles
O=C([C@H](CC(C)C)N1CC(OC2=C(Cl)C=CC=C2)=CC1=O)NC3=NN(C=C3)C[C@H](CO)O
Molecular Weight
462.93
References & Citations
[1]Zhu XX, et al. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection. Diabetes Obes Metab. 2018 Sep;20(9):2113-2120.|[2]Wang P, et al. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. J Diabetes Res. 2017;2017:5812607.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-109030R/Dorzagliatin-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-109030R/
Clinical Information
No Development Reported
CAS Number
1191995-00-2
Curated Selection
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