Entinostat-d4

Entinostat-d4 is the deuterium labeled Entinostat[1]. Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively[2].

Product Specifications

Product Name Alternative

MS-275-d4; SNDX-275-d4

UNSPSC

12352005

Target

Apoptosis; Autophagy; HDAC

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

90.31

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=C(C=C1)C(NC2=C([2H])C([2H])=C([2H])C([2H])=C2N)=O)OCC3=CC=CN=C3

Molecular Formula

C21H16D4N4O3

Molecular Weight

380.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Lauffer BE, et al. Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem. 2013 Sep 13;288 (37) :26926-43.