Entinostat-d4
Product Specifications
Product Name Alternative
MS-275-d4; SNDX-275-d4
UNSPSC Description
Entinostat-d4 is the deuterium labeled Entinostat[1]. Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively[2].
Target Antigen
Apoptosis; Autophagy; HDAC
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics
Field of Research
Cancer
Purity
90.31
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=C(C=C1)C(NC2=C([2H])C([2H])=C([2H])C([2H])=C2N)=O)OCC3=CC=CN=C3
Molecular Weight
380.43
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Lauffer BE, et al. Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem. 2013 Sep 13;288(37):26926-43.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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