β-Glucogallin

β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC50 value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research[1][2][3][4][5].

Product Specifications

CAS Number

[13405-60-2]

Product Name Alternative

1-O-Galloyl-β-D-glucose

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H319, H335

Target

Aldose Reductase; NF-κB; PDGFR; Reactive Oxygen Species (ROS) ; SOD

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/β-glucogallin.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 4.17 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)O[C@H](CO)[C@@H](O)[C@@H]1O

Molecular Formula

C13H16O10

Molecular Weight

332.26

Precautions

H302+H312+H332, H319, H335

References & Citations

[1]Li L, et al. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57 (1) :71-7.|[2]Ma Y, Liu F, Xu Y. Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells. Med Sci Monit. 2019 Dec 7;25:9310-9318. |[3]Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012;7 (4) :e31399.|[4]Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57 (1) :71-7.|[5]Majeed M, et al. Amelioration of carbon tetrachloride induced hepatotoxicity by Β-glucogallin, a gallic acid derivative of emblica officinalis gaertn. (euphorbiaceae) . Science, 2015, 4 (7) : 696-701.