Tauroursodeoxycholate (sodium)
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
Product Specifications
CAS Number
[35807-85-3]
Product Name Alternative
Tauroursodeoxycholic acid (sodium) ; TUDCA (sodium) ; UR 906 (sodium)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; Endogenous Metabolite; ERK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tauroursodeoxycholate-Sodium.html
Concentration
10mM
Purity
98.40
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C26H44NNaO6S
Molecular Weight
521.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92 (2) :307-16.|[2]Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53 (3) :337-345.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Caspase 12; Caspase 3; ERK; Human Endogenous Metabolite
Citation 01
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