(2R,3S) -Azelaprag

(2R,3S) -Azelaprag ((2R,3S) -AMG 986) (Example 238.0) is a precursor of an apelin receptor agonist (EC50=12 nM) and an isomer of Azelaprag (HY-109111) [1].

Product Specifications

CAS Number

[2049979-31-7]

Product Name Alternative

(2R,3S) -AMG 986

UNSPSC

12352005

Target

Apelin Receptor (APJ) ; Drug Isomer

Type

Reference compound

Related Pathways

GPCR/G Protein; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/2r-3s-azelaprag.html

Purity

99.10

Solubility

DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=S(NC1=NN=C(C2=CN=CC(C)=C2)N1C(C(OC)=CC=C3)=C3OC)([C@H](C)[C@H](C4=NC=C(C)C=N4)C)=O

Molecular Formula

C25H29N7O4S

Molecular Weight

523.61

References & Citations

[1]Chen Ning, et al. Triazole agonists of the apj receptor. WO2016187308A1. 2016-11-24.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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