2-Bromohexadecanoic acid

2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis[1].

Product Specifications

CAS Number

[18263-25-7]

Product Name Alternative

2-Bromopalmitic acid; 2-Bromopalmitate

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Pyroptosis

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-bromohexadecanoic-acid.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : ≥ 125 mg/mL

Smiles

CCCCCCCCCCCCCCC(Br)C(O)=O

Molecular Formula

C16H31BrO2

Molecular Weight

335.32

Precautions

H315, H319, H335

References & Citations

[1]Hu L, et al. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate. Cell Death Dis. 2020 Apr 24;11 (4) :281.