Acetaminophen-d4

Acetaminophen-d4 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

Product Specifications

CAS Number

[64315-36-2]

Product Name Alternative

Paracetamol-d4; 4-Acetamidophenol-d4; 4'-Hydroxyacetanilide-d4

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

COX; Endogenous Metabolite; Histone Acetyltransferase

Type

Isotope-Labeled Compounds

Related Pathways

Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Purity

99.60

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC1=C(C([2H])=C(C([2H])=C1[2H])NC(C)=O)[2H]

Molecular Formula

C8H5D4NO2

Molecular Weight

155.19

Precautions

H302, H312, H332

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.