Astaxanthin

Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5].

Product Specifications

CAS Number

[472-61-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; NF-κB; PPAR; Reactive Oxygen Species (ROS) ; STAT

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Astaxanthin.html

Purity

98.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : Acetone mixture (1:1) : 2 mg/mL (ultrasonic; warming; heat to 60°C) |THF : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(/C=C/C(C(C)(C[C@H](O)C1=O)C)=C1C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(C[C@H](O)C2=O)C)=C2C

Molecular Formula

C40H52O4

Molecular Weight

596.84

Precautions

H302, H315, H319, H335

References & Citations

[1]Sun SQ, et al. Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer. Mar Drugs. 2020 Aug 7;18 (8) :415. |[2]Fu D, et al. Effect of astaxanthin on retinal pigment epithelial cells in high glucose: an in-vitro study. Biomed Res, 2017, 28 (15) : 6839-6843. |[3]Zhang X, et al. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells. Arch Biochem Biophys. 2011 Aug 1;512 (1) :96-106. |[4]Gross GJ, et al. Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats. Mol Cell Biochem. 2006 Feb;283 (1-2) :23-30. |[5]Zhang L, et al. Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Mar Drugs. 2015 Jul 14;13 (7) :4310-30.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

PPARγ; STAT3

Available Sizes

Curated Selection

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