Benzonatate
Benzonatate (Benzononatine) is an orally active and non-narcotic peripheral antitussive agent. Benzonatate is a reversible voltage-gated Na+ channels inhibitor. Benzonatate dampens the activity of cough stretch receptors[1][2].
Product Specifications
CAS Number
[104-31-4]
Product Name Alternative
Benzononatine
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/benzonatate.html
Purity
98.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)C1=CC=C(NCCCC)C=C1
Molecular Formula
C30H53NO11
Molecular Weight
603.74
Precautions
H315, H319, H320
References & Citations
[1]Teo S, et al. The Antitussive Benzonatate Is Not Tumorigenic in Rodent Carcinogenicity Studies. Toxicol Pathol. 2018;46 (6) :683-692. |[2]Evans MS, et al. Benzonatate inhibition of voltage-gated sodium currents. Neuropharmacology. 2016 Feb;101:179-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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