Helianorphin-19
Product Specifications
UNSPSC Description
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain[1].
Target Antigen
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/helianorphin-19.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC1=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCC3)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=C(O)C=C5
Molecular Weight
1790.21
References & Citations
[1]Muratspahić E, et al. Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain. J Med Chem. 2021 Jul 8;64(13):9042-9055.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5907/Helianorphin-19-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5907/
Clinical Information
No Development Reported
CAS Number
2883653-86-7
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