PF-4708671

PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.

Product Specifications

CAS Number

[1255517-76-0]

UNSPSC

12352005

Hazard Statement

H301

Target

Autophagy; Ribosomal S6 Kinase (RSK)

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PF-4708671.html

Purity

99.87

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

FC(C1=CC=C2N=C(CN3CCN(C4=NC=NC=C4CC)CC3)NC2=C1)(F)F

Molecular Formula

C19H21F3N6

Molecular Weight

390.41

Precautions

H301

References & Citations

[1]Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) . Biochem J. 2010 Oct 15;431 (2) :245-55.|[2]Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14 (3) :799-809.