2-Phenylacetamide

2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active[1][2].

Product Specifications

CAS Number

[103-81-1]

UNSPSC

12352005

Hazard Statement

H301, H319

Target

Endogenous Metabolite; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-phenylacetamide.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N)CC1=CC=CC=C1

Molecular Formula

C8H9NO

Molecular Weight

135.17

Precautions

H301, H319

References & Citations

[1]Zeng M, et al., 2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo. Molecules. 2018 Sep 7;23 (9) :2293.|[2]Yuan PP, et al., 2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats. BMC Complement Med Ther. 2023 Jun 23;23 (1) :207.