SARM1 Polyclonal Antibody
This is a SARM1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
NAD (+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD (+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD (+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD (+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide; NAD (+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP (+, but not other NAD (+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Synonyms
SARM, HsTIR, SAMD2, hSARM1, MyD88-5
Gene ID
23098
Swiss Prot
Q6SZW1
Reactivity
Human
Immunogen
A synthetic peptide of human SARM1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IP
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IP 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
50kDa
Observed Molecular Weight
58KDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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