SARM1 Polyclonal Antibody
This is a SARM1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
NAD (+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD (+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD (+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD (+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide; NAD (+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP (+, but not other NAD (+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Synonyms
SARM, HsTIR, SAMD2, hSARM1, MyD88-5
Gene ID
23098
Swiss Prot
Q6SZW1
Reactivity
Human
Immunogen
A synthetic peptide of human SARM1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IP
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IP 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
50kDa
Observed Molecular Weight
58KDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
NBP3-27989AF750 0.1 mL
Human Monoclonal IL-18/IL-1F4 Antibody (GSK 1070806) [Alexa Fluor 750]
Ask
View Details