ARN14494

ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research[1].

Product Specifications

CAS Number

[1037837-27-6]

UNSPSC

12352005

Target

Apoptosis; COX; Interleukin Related; NO Synthase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/arn14494.html

Purity

99.08

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(N(C3CCN(CC(N4CC5C(CCC5)C4)=O)CC3)C(C2)=O)C=C1)NC

Molecular Formula

C24H32N4O3

Molecular Weight

424.54

References & Citations

[1]De Vita T, et al. Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1-42 Injury. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1627-1635.