Norgestimate

Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2]. Norgestimate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[35189-28-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H361

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/norgestimate.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C#C[C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=C/C(CC[C@]4([H])[C@@]3([H])CC[C@]12CC)=N/O

Molecular Formula

C23H31NO3

Molecular Weight

369.50

Precautions

H302, H315, H319, H361

References & Citations

[1]Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68 (10-13) :879-90.|[2]Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167 (4 Pt 2) :1191-6.