DSP Polyclonal Antibody
This is a DSP Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Synonyms
250/210 kDa paraneoplastic pemphigus antigen, DCWHKTA, Desmoplakin (DPI DPII), Desmoplakin, Desmoplakin I, Desmoplakin II, DESP, DP, DP I, DP II, DPI, DPII, DSP, KPPS2, PPKS 2, PPKS2
Swiss Prot
P15924
Accession Number
NP_004406
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human DSP
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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