IRAK1BP1 Polyclonal Antibody
This is a IRAK1BP1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Synonyms
ActA binding protein 3, AIP70, Interleukin 1 receptor associated kinase 1 binding protein 1, IRAK1-binding protein 1, Signaling molecule that associates with Pelle-like kinase, SIMPL
Swiss Prot
Q5VVH5
Accession Number
BC112253
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human IRAK1BP1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.4 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
29 kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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