Danthron

Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

Product Specifications

CAS Number

[117-10-2]

Product Name Alternative

Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H351

Target

AMPK; Autophagy; Bacterial; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Danthron.html

Purity

99.41

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C=CC=C2O)C(C3=CC=CC(O)=C13)=O

Molecular Formula

C14H8O4

Molecular Weight

240.21

Precautions

H315, H319, H335, H351

References & Citations

[1]Zhou R, et al. Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro. Acta Pharmacol Sin. 2013 Aug;34 (8) :1061-9.|[2]Zhang H, et al. Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem. 2011 Jan 21;286 (3) :1868-75.