Mitoxantrone
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity[1][2][3][4]. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].
Product Specifications
CAS Number
[65271-80-9]
Product Name Alternative
Mitozantrone; NSC 301739
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Endogenous Metabolite; Orthopoxvirus; PKC; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/mitoxantrone.html
Concentration
10mM
Purity
99.58
Solubility
DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O
Molecular Formula
C22H28N4O6
Molecular Weight
444.48
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PKC; Topo II
Citation 01
Available Sizes
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