HIPK3 Polyclonal Antibody

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) .

Androgen receptor interacting nuclear protein kinase, Androgen receptor-interacting nuclear protein kinase, ANPK, DYRK6, Fas interacting serine/threonine protein kinase, Fas-interacting serine/threonine-protein kinase, FIST, FIST3, Hipk3, HIPK3, homeodomain interac