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Anti-human CD4 Monoclonal Antibody PE Conjugated, Flow Validated

Flow Cytometry

Product Specifications

Background

CD stands for "cluster of differentiation"; the number that follows is arbitrarily assigned. In the full designation the cell type and nature and molecular weight of the antigen are given in brackets; for CD4, this is as follows: [T, gp55]. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.

Synonyms

T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4; CD4

Gene Name

CD4

UniProt

P01730

Host

Mouse

Reactivity

Human, Rhesus monkey, Cynomolgus monkey

Immunogen

Human peripheral blood T lymphocytes

Clonality

Monoclonal

Clone

Clone: Clone: OKT4

Conjugation

PE

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Antiviral Signaling, Hematopoietic Progenitors, Immune System Diseases, Immunology, Lymphoid, Myeloid, Stem Cells, T Cells, T Lymphocytic Lineage

Purification

Protein A purified

Sensitivity

5ul per sample

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

User needs to optimize the dilution ratio for this antibody.

Form

Liquid

Function

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Molecular Weight

51111 MW

Shipping Conditions

Available

Storage Conditions

Store at 2-8°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=FC00344-PE

Product MSDS

https://www.bosterbio.com/msds?sku=FC00344-PE

Fragment

IgG2b, k

Other Gene Names

T-cell surface glycoprotein CD4

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Protein Name

T-cell surface glycoprotein CD4

Available Sizes

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