Raffinose

Raffinose (Melitose) regulates intestinal flora, inhibits TLR4-MyD88-NF-κB signaling pathway, and activates Nrf2 signaling pathway. Raffinose exhibits anti-inflammatory, antioxidant, and immunomodulatory activities. Raffinose is orally active[1][2][3].

Product Specifications

CAS Number

[512-69-6]

Product Name Alternative

Melitose

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Keap1-Nrf2; MyD88; NF-κB; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Autophagy; Immunology/Inflammation; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/raffinose.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 250 mg/mL (ultrasonic)

Smiles

OC[C@]1(O[C@H](CO)[C@@H](O)[C@@H]1O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO[C@H]3O[C@@H]([C@H](O)[C@H](O)[C@H]3O)CO

Molecular Formula

C18H32O16

Molecular Weight

504.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang P, et al., Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4-MyD88-NF-κB Signaling Pathway. Foods. 2024 Jun 13;13 (12) :1849. |[2]Lin S, et al., Raffinose increases autophagy and reduces cell death in UVB-irradiated keratinocytes. J Photochem Photobiol B. 2019 Dec;201:111653. |[3]Liu J, et al., Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD. Phytomedicine. 2024 Jul 25;130:155756.