Acitretin

Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease[1][2][3].

Product Specifications

CAS Number

[55079-83-9]

Product Name Alternative

Ro 10-1670

UNSPSC

12352005

Hazard Statement

H315, H319, H360, H410

Target

Apoptosis; Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/acitretin.html

Purity

99.62

Solubility

DMSO : 11.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

CC(/C=C/C(C(C)=CC(OC)=C1C)=C1C)=C\C=C\C(C)=C\C(O)=O

Molecular Formula

C21H26O3

Molecular Weight

326.43

Precautions

H315, H319, H360, H410

References & Citations

[1]Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6 (10) :1725-34.|[2]Sengör B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20 (6) :689-92.|[3]Guilherme MDS, et, al. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019 Jul 23;11:182.