Zoniporide

Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM) . Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].

Product Specifications

CAS Number

[241800-98-6]

Product Name Alternative

CP-597396

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Na+/H+ Exchanger (NHE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/zoniporide.html

Purity

99.89

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O

Molecular Formula

C17H16N6O

Molecular Weight

320.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Marala, et al. "Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1." European journal of pharmacology 451.1 (2002) : 37-41.