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Anti-Vinculin VCL Antibody (biotin)

Boster Bio Anti-Vinculin VCL Antibody (biotin) (Catalog # A01207-1-Biotin) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat, Rabbit, Chicken.

Product Specifications

Background

Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1) . Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2) . Expression of vinculin were shown to be affected by the level of actin expression (2,3) . Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4) . Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5) .

Synonyms

CMD1W, CMH15, Metavinculin, MVCL

Gene Name

VCL

UniProt

P18206

Host

Rabbit

Reactivity

Human, Mouse, Rat, Rabbit, Chicken

Cross Reactivity

Biotin-Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.

Immunogen

Biotin-Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin.

Clonality

Polyclonal

Conjugation

Biotin

Tissue Specificity

Metavinculin is muscle-specific.

Applications

ELISA, WB

Field of Research

Homeostasis

Purification

Biotin-Vinculin antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Actin filament (F-actin) -binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Molecular Weight

123799 MW

Shipping Conditions

Available

Storage Conditions

Biotin-Vinculin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01207-1-Biotin

Product MSDS

https://www.bosterbio.com/msds?sku=A01207-1-Biotin

Fragment

IgG

Applications Notes

Western blot, 0.1-0.25μg/ml, Human, Mouse, Rat, Monkey<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human<br> Immunofluorescence, 2μg/ml, Human<br> Flow Cytometry (Fixed), 1-3μg/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5μg/ml, -<br>

Other Gene Names

Vinculin

Subcellular Location

Cell membrane

Protein Name

Vinculin

Available Sizes

Curated Selection

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