Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Toll-interacting protein Tollip Antibody Picoband®

Boster Bio Anti-Toll-interacting protein Tollip Antibody catalog # PA2005. Tested in Flow Cytometry, ICC, IHC, IF, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

TOLLIP (TOLL-Interacting Protein), is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene. Lo et al. (2009) stated that the TOLLIP gene maps to chromosome 11. The mouse gene maps to chromosome 7. By Western blot analysis of embryonic kidney cells, Burns et al. (2000) confirmed the binding of TOLLIP to IL1RAP, to a complex of IL1RAP-IL1R1, and to IL18R. Burns et al. (2000) proposed that IL1B stimulation induces aggregation of IL1Rs, recruitment of MYD88 followed by TOLLIP-IRAK complexes, and the phosphorylation of IRAK by MYD88. This leads to the dissociation of TOLLIP from IRAK, which can then transmit the IL1-induced signals.

Synonyms

Toll-interacting protein; TOLLIP

Gene Name

Toll-interacting protein

UniProt

Q9H0E2

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Tollip.

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cytokines, Immunoglobulins, Immunology, Innate Immunity, Interleukins, Receptors, TLR Signaling

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856) . Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851) . .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA2005

Product MSDS

https://www.bosterbio.com/msds?sku=PA2005

Fragment

Rabbit IgG

Applications Notes

6

Other Gene Names

TOLLIP

Subcellular Location

Cytoplasm .

Sequence Similarities

Belongs to the tollip family.

Protein Name

Toll-interacting protein

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

PPP3R1 Rabbit pAb
E2500954 100ul

PPP3R1 Rabbit pAb

Ask
View Details
M33 (G-5) Alexa Fluor® 790
sc-515914 AF790 200 µg/mL

M33 (G-5) Alexa Fluor® 790

Ask
View Details
Rabbit anti-Escherichia coli O17:K52:H18 (strain UMN026/ExPEC) atpE Polyclonal Antibody
MBS7177309 Inquire

Rabbit anti-Escherichia coli O17:K52:H18 (strain UMN026/ExPEC) atpE Polyclonal Antibody

Ask
View Details
Recombinant Caenorhabditis elegans Uncharacterized protein R10E12.2 (R10E12.2)
MBS1074337-01 0.02 mg (E-Coli)

Recombinant Caenorhabditis elegans Uncharacterized protein R10E12.2 (R10E12.2)

Ask
View Details
Recombinant Caenorhabditis elegans Uncharacterized protein R10E12.2 (R10E12.2)
MBS1074337-02 0.02 mg (Yeast)

Recombinant Caenorhabditis elegans Uncharacterized protein R10E12.2 (R10E12.2)

Ask
View Details
Recombinant Caenorhabditis elegans Uncharacterized protein R10E12.2 (R10E12.2)
MBS1074337-03 0.1 mg (E-Coli)

Recombinant Caenorhabditis elegans Uncharacterized protein R10E12.2 (R10E12.2)

Ask
View Details