Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CD163 Antibody Picoband®

Boster Bio Anti-CD163 Antibody catalog # PA1874-1. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Synonyms

Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; CD163; Soluble CD163; sCD163; CD163; M130

Gene Name

Scavenger receptor cysteine-rich type 1 protein M130

UniProt

Q86VB7

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human CD163 recombinant protein (Position: F1056-L1165) .

Clonality

Polyclonal

Tissue Specificity

Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. .

Applications

IHC, WB

Field of Research

Atherosclerosis, Cardiovascular, Cell Type Markers, Immunology, Innate Immunity, Macrophage/Inflammation, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA1874-1

Product MSDS

https://www.bosterbio.com/msds?sku=PA1874-1

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, By Heat<br>

Other Gene Names

CD163

Subcellular Location

Soluble CD163: Secreted.

Sequence Similarities

Contains 9 SRCR domains.

Protein Name

Scavenger receptor cysteine-rich type 1 protein M130

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

PTPRT Protein Lysate (Human) with C-Ha Tag
38186031 100 μg

PTPRT Protein Lysate (Human) with C-Ha Tag

Ask
View Details
Fgf14 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
20491114 3 x 1.0 µg

Fgf14 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

Ask
View Details
PRMT7 CRISPR/Cas9 KO Plasmid (h)
sc-417516 20 µg

PRMT7 CRISPR/Cas9 KO Plasmid (h)

Ask
View Details
Recombinant Clostridium tetani Alanine--tRNA ligase (alaS), partial
MBS1432959 Inquire

Recombinant Clostridium tetani Alanine--tRNA ligase (alaS), partial

Ask
View Details
Human B Cell Activation Factor ELISA Kit
E01B0309-01 48 Well

Human B Cell Activation Factor ELISA Kit

Ask
View Details
Human B Cell Activation Factor ELISA Kit
E01B0309-02 96 Well

Human B Cell Activation Factor ELISA Kit

Ask
View Details