Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-IKK gamma/IKBKG Antibody Picoband®

Boster Bio Anti-IKK gamma/IKBKG Antibody catalog # PA1551. Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

NF-kappa-B essential modulator (NEMO), also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ), is a protein that in humans is encoded by the IKBKG gene. This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Synonyms

NF-kappa-B essential modulator; NEMO; IkB kinase-associated protein 1; IKKAP1; mFIP-3; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier; Ikbkg; Nemo

Gene Name

NF-kappa-B essential modulator

UniProt

O88522

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of mouse IKK gamma, different from the relative rat sequence by three amino acids.

Clonality

Polyclonal

Applications

WB

Field of Research

Apoptosis, Apoptotic Markers, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cell Death, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Intracellular, NFKB Pathway, Nuclear Signaling, Nuclear Signaling Pathways, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway, TLR Signaling, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA1551

Product MSDS

https://www.bosterbio.com/msds?sku=PA1551

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Mouse<br>

Other Gene Names

IKBKG

Subcellular Location

Cytoplasm . Nucleus .

Sequence Similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.

Protein Name

NF-kappa-B essential modulator (NEMO)

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human GNA11 knockdown cell line
ABC-KD6166 1 Vial

Human GNA11 knockdown cell line

Ask
View Details
Human CCL2 ELISA Kit
MBS9719257-01 48 Tests

Human CCL2 ELISA Kit

Ask
View Details
Human CCL2 ELISA Kit
MBS9719257-02 96 Tests

Human CCL2 ELISA Kit

Ask
View Details
Human CCL2 ELISA Kit
MBS9719257-03 5x 96 Tests

Human CCL2 ELISA Kit

Ask
View Details
FITC anti-mouse CD45.2
E16FMF045.2-500U 500 μg

FITC anti-mouse CD45.2

Ask
View Details
Human Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) ELISA Kit
MBS2703861-01 24 Strip Well

Human Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) ELISA Kit

Ask
View Details