Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Tau/MAPT Antibody Picoband®

Boster Bio Anti-Tau/MAPT Antibody catalog # PA1482. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

MAPT, Microtubule-associated protein tau, appears to be enriched in axons. The MAPT gene is assigned to chromosome 17 by hybridization of a cDNA clone to flow-sorted and spot-blotted chromosomes and to 17q21 by in situ hybridization, containing 16 exons. The tau proteins are the product of alternative splicingfrom a single gene that in humans is designated MAPT. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons in the central nervous system and are less common elsewhere. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.

Synonyms

Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL, MTBT1, TAU

Gene Name

Microtubule-associated protein tau

UniProt

P10636

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Tau, different from the related mouse and rat sequences by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Applications

WB

Field of Research

Alzheimer's Disease, Cell Type Marker, Cytoskeleton, Cytoskeleton/ECM, Microtubules, Neurodegenerative Disease, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA1482

Product MSDS

https://www.bosterbio.com/msds?sku=PA1482

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat<br>

Other Gene Names

MAPT

Subcellular Location

Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Sequence Similarities

Contains 4 Tau/MAP repeats.

Protein Name

Microtubule-associated protein tau

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rabbit Polyclonal ZBTB8B Antibody
NBP2-83789-0.1mL 0.1 mL

Rabbit Polyclonal ZBTB8B Antibody

Ask
View Details
ACTN4 Antibody (C-term)
E45R07050G-1 100 ul

ACTN4 Antibody (C-term)

Ask
View Details
Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit
SL1065Mo-01 48 Tests

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

Ask
View Details
Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit
SL1065Mo-02 96 Tests

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

Ask
View Details
Porcine Cholesteryl Ester Transfer Protein (CETP) ELISA Kit
MBS260811-01 48 Well

Porcine Cholesteryl Ester Transfer Protein (CETP) ELISA Kit

Ask
View Details
Porcine Cholesteryl Ester Transfer Protein (CETP) ELISA Kit
MBS260811-02 96 Well

Porcine Cholesteryl Ester Transfer Protein (CETP) ELISA Kit

Ask
View Details