Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-VEGF/VEGFA Antibody Picoband®

Anti-VEGF

Product Specifications

Background

VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. It may be a major regulator of tumor angiogenesis in vivo. Vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. It is, however, structurally related to platelet-derived growth factor. VEGF shares homology with the PDGF A chain and B chain, including conservation of all 8 cysteines found in PDGFA and PDGFB. VEGF gene contains 8 exons. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo.

Synonyms

Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF; VEGFA; VEGF

Gene Name

Vascular endothelial growth factor A

UniProt

P15692

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human VEGF, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. .

Applications

IHC, WB

Field of Research

Angiogenesis, Cancer, Cancer Metabolism, Cardiovascular, Growth Factors, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA1080

Product MSDS

https://www.bosterbio.com/msds?sku=PA1080

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, By Heat<br>

Other Gene Names

VEGFA

Subcellular Location

Secreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Sequence Similarities

Belongs to the PDGF/VEGF growth factor family.

Protein Name

Vascular endothelial growth factor A (VEGF-A)

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ZFAND1 (1-268, His-tag) Human Protein
AR50902PU-N 250 µg

ZFAND1 (1-268, His-tag) Human Protein

Ask
View Details
Shpk Mouse shRNA Plasmid (Locus ID 74637)
TL505009 1 Kit

Shpk Mouse shRNA Plasmid (Locus ID 74637)

Ask
View Details
Anti Mouse F4/80 Flow Cytometry Monoclonal Clone CIA31 EV450 100ug
IRTAMSF480CIA31CEV450100UG 100 µg

Anti Mouse F4/80 Flow Cytometry Monoclonal Clone CIA31 EV450 100ug

Ask
View Details
ELISA Kit For Retinoic acid receptor RXR-gamma
E13526c 96 Tests

ELISA Kit For Retinoic acid receptor RXR-gamma

Ask
View Details
Falcon Transparent 1um Pet Membrane For 6 Well Plate
353102 48 Pack

Falcon Transparent 1um Pet Membrane For 6 Well Plate

Ask
View Details
Recombinant Escherichia coli Uncharacterized protein ybjC (ybjC)
MBS1253978-01 0.02 mg (E-Coli)

Recombinant Escherichia coli Uncharacterized protein ybjC (ybjC)

Ask
View Details